RSN
Rafael S. Nascimento
Ping Wu, Jie Yan, Yung-Chih Lai, Chen Siang Ng, Ang Li, Xueyuan Jiang, Ruth Elsey, Randall Widelitz, Ruchi Bajpai, Wen-Hsiung Li & Cheng-Ming Chuong (2017)
Multiple regulatory modules are required for scale-to-feather conversion
Molecular Biology and Evolution, msx295, (advance online publication)
doi: https://doi.org/10.1093/molbev/msx295
https://academic.oup.com/mbe/advanc...molbev/msx295/4627828?redirectedFrom=fulltext
Abstract
The origin of feathers is an important question in Evo-Devo studies, with the eventual evolution of vaned feathers which are aerodynamic, allowing feathered dinosaurs and early birds to fly and venture into new ecological niches. Studying how feathers and scales are developmentally specified provides insight into how a new organ may evolve. We identified feather-associated genes using genomic analyses. The candidate genes were tested by expressing them in chicken and alligator scale forming regions. Ectopic expression of these genes induced intermediate morphotypes between scales and feathers which revealed several major morphogenetic events along this path: localized growth zone formation, follicle invagination, epithelial branching, feather keratin differentiation and dermal papilla formation. In addition to molecules known to induce feathers on scales (retinoic acid, β-catenin), we identified novel scale-feather converters (Sox2, Zic1, Grem1, Spry2, Sox18) which induce one or more regulatory modules guiding these morphogenetic events. Some morphotypes resemble filamentous appendages found in feathered dinosaur fossils, while others exhibit characteristics of modern avian feathers. We propose these morpho-regulatory modules were used to diversify archosaur scales and to initiate feather evolution. The regulatory combination and hierarchical integration may have led to the formation of extant feather forms. Our study highlights the importance of integrating discoveries between developmental biology and paleontology.
Multiple regulatory modules are required for scale-to-feather conversion
Molecular Biology and Evolution, msx295, (advance online publication)
doi: https://doi.org/10.1093/molbev/msx295
https://academic.oup.com/mbe/advanc...molbev/msx295/4627828?redirectedFrom=fulltext
Abstract
The origin of feathers is an important question in Evo-Devo studies, with the eventual evolution of vaned feathers which are aerodynamic, allowing feathered dinosaurs and early birds to fly and venture into new ecological niches. Studying how feathers and scales are developmentally specified provides insight into how a new organ may evolve. We identified feather-associated genes using genomic analyses. The candidate genes were tested by expressing them in chicken and alligator scale forming regions. Ectopic expression of these genes induced intermediate morphotypes between scales and feathers which revealed several major morphogenetic events along this path: localized growth zone formation, follicle invagination, epithelial branching, feather keratin differentiation and dermal papilla formation. In addition to molecules known to induce feathers on scales (retinoic acid, β-catenin), we identified novel scale-feather converters (Sox2, Zic1, Grem1, Spry2, Sox18) which induce one or more regulatory modules guiding these morphogenetic events. Some morphotypes resemble filamentous appendages found in feathered dinosaur fossils, while others exhibit characteristics of modern avian feathers. We propose these morpho-regulatory modules were used to diversify archosaur scales and to initiate feather evolution. The regulatory combination and hierarchical integration may have led to the formation of extant feather forms. Our study highlights the importance of integrating discoveries between developmental biology and paleontology.
