Yes, some people get fine digiscoping results with removable lens cameras, but I do not. The major problem I have, even with the 4/3rds cameras, is shutter shock when the curtain rumbles across the sensor and jars the scope and camera. An electronic shutter may not solve the problem in that it only allows limited video resolution in some cameras. In others it may be a rolling scroll that is open much longer than the same exposure time with a mechanical camera and allows distortion.
A small sensor, such as in my Lumix FH-1 ( fs-10) is allows a shutter speed four times as fast as a 4/3 camrera, and 16 times as fast as a full frame sensor. I do not agree that the larger cameras can fully compensate by increasing the ISO with impunity. At most they may reclaim half of the lost speed without suffering quality loss compared with the point and shoot cameras. Go ahead, visit the IR comparometer and demonstrate the effects to yourself.
Small cameras digiscope near their sharpest optical design aperture, a stop or two below full open. With interchangable lenses people may use an f/2 lens at the scope determined f/stop of f/11 or f/16. Not a condition expected to produce the sharpest image.
A point and shoot camera using contrast autofocus detection will focus much better than a typical SLR. My favorite Lumix FH-1 (FS-10) is quite sharp and only weighs 120 grams and mounts nicely on the outer screw threads of a Baader Hyperion 17mm eyepiece, which is known to digiscope well. I attach threads to the body of the camera and connect with extension tubes. See my attached image of a sparrow shot at 40 feet. Click on the image for a larger view.
http://farm9.staticflickr.com/8304/7778422664_71b4cede51_b.jpg
I enjoy digiscoping with the little 120 gram Lumix. Cannot imagine using a camera that weighs another pound. The extra weight can distort the eyepiece and/or lens mounting, which is very critical to the collimation of the scope. Of course for a legitimate mounting a balance bar could be added that would weigh another pound. Gene