Heh! There are whole
books on sharpening techniques - this could turn into a long discussion!
It really depends on the intended output of the image, the software in use and - to a large extent - how sharp the image is to start with.
It also matters which camera - I've known for a long time that my 7D takes sharpening much better than cameras with lower pixel densities, and actually needs different levels of sharpening than (say) my 40D does.
For what it's worth, the most important thing I've found with regard to sharpening is to apply it
selectively: I always apply sharpening on a layer, then erase it from the parts of the image (the background, the sky) where I don't want it. That way you can be surprisingly aggressive with sharpening it you need to be.
Something I've noticed on numerous occasions - and I find it now - is that the sharpening algorithms that are provided in noise reduction software plug-ins are often (to my eyes) more satisfying than the well-known sharpening tools in Photoshop like USM and even Smart Sharpening: so I do most of my sharpening (having done light capture sharpening on conversion from RAW to tiff) with the "Reduce Blur" slider in the Topaz DeNoise NR plug-in.
It just seems to produce what to my eyes is a more natural result than the "official" sharpening tools - still applied on a layer and then erased from where it isn't needed.
Are you using Paint Shop Pro by any chance, Ryan (the sharpening options you mention are both present in their own right as PSP tools)?
If so, try the "Focus" tool in the (IIRC) "Adjust > Photo Fix" sub menu - I loved it when I used PSP.
Added: Ah - just looked again at the title of your post!
There's as many "best" ways to sharpen as there are photographers, but my approach definitely works for me. I should say that I don't like a sharp
ened look to my images, I like 'em to look natural.
(All handheld, Canon 7D and 100-400mm lens):