Good timing, as I have had many Nikon ED scopes going back thirty years, including the ED50. I have tried the ED50 with many Nikon eyepieces (since I had them) and think the 16x wide is the best - but as I write this I realize I have not tried the 27x fixed. I recently bought an Opticron MM4 50mm with the SDL3 eyepiece to compare. For reference, my other scope is a top sample of the Kowa 884.
Here's my findings, some of which I've discussed before elsewhere:
Optically, the Nikon w the 16x wide surpasses the Opticron in pretty much every way. It is sharper, brighter, has a much wider field, and has a luminous quality that puts it into the upper echelons of scopes (though not the top). However, by memory, the Opticron is about on par with the Nikon when I used it with a zoom (several, old and new). This is all to say however the Opticron is very good - I like it a lot - but just not at the level of the Nikon.
I also prefer the Nikon focuser - it's a single, and easy to get just right - less fuss than the Opticron dual (which isn't bad, just a relative comparison of preference).
HOWEVER, there are other considerations.
The Nikon ED50 is known for poor quality control out the gates, and also to be delicate. I went through two previous ED50s prior to the one I have now. One had a sticky prism that would "judder" when focusing, and a trip back to Nikon didn't resolve it (it was not super noticeable but to me unacceptable, I think they thought it was fine). The second broke in half in my day pack - I still have no idea how it happened, as I wasn't being abusive, but also not being gentle. The third has been fine and optically the best of them as well. I tried the Opticron wondering if it would be on par optically, and if so keep it as a more durable alternative.
I have no experience with the Opticron durability, but it strikes me at least externally as tougher. I like the clamshell body design that resists pressure/breakage along the long axis. Terrific lens covers front and back (why can't everyone do those?). Just overall a sense of being better built (but I wouldn't go crazy - this is plastic at the end of the day).
Here's the bottom line for me: If you you need the small size, and are going to be using the scope a lot, or going on a major trip, esp one in the wilds (say a backcountry birding/wildlife trip), get the Opticron. It is a fine scope, and I think less likely to break/let you down - a very good scope is better than no scope, esp for a special trip. However, if you are mostly doing day birding/daypack etc. birding, or just want a lighter scope, and a return is no big deal, get the Nikon (I do note however I hate the semi-disposable aspect, esp after having the completely tough/legacy grade aluminum Nikon EDs). If maximum durability is a question, I'd actually probably find a top used Nikon ED3 60mm - that is a tough, waterproof scope.
Finally, my plan will be to epoxy the body seam on the Nikon. That's where it split before, I've heard others have that happen, and hopefully that will help (and also render the scope unrepairable, but whatever).