The farther you are from your subject the more atmosphere gets in the way and the more the qualities of that atmosphere influence the IQ. Heat is the big one to watch for - think of the effects of heat haze on the appearance of a scene, but also, I think, humidity, dust and maybe wind or thermal gradients also have an impact. Even things which may not appear visible to the naked eye can become very evident when magnified by a big lens and followed up with pixel peeping.
This will not only impact image quaility, it will also have a huge influence on the hit and miss rate of the AF system.
Ever used a car in the winter as blind and shot through the open window? If the temperature in the car is not close to the ambient outside temperature the warm air leaving the car through the open window will cause the AF to do strange things as it tries to lock on a target. If it does the blurry image caused by temperature turbulence tells the story. Your eye will see very little or nothing of all this going on.
Ulli