As far as I understand, binoculars are tiny telescopes aligned together (forgive any lack of technical correction, not sure if alignment and collimation are exact synonyms), and in order to give a satisfactory experience, the two tubes must be aligned to a quite small tolerance. So:
- if the difference is quite big, you will simply see two different images, and your brain won't be able to fix it or merge them in one single image (what any properly adjusted binocular does), this is why sometimes many viewers claim to "see double", like if they were drunk; a double image is a clear sign of a severe lack of alignment.
- however, even if everything looks OK from the outside, the two tubes can still be poorly aligned, in some cases not enough to cause double vision, but indeed to "force" your brain in order to merge those images into one. So, you can use the binoculars, you get an apparently "correct image" (a single focused subject), but when you put the binoculars down you feel discomfort, as in eyestrain or headache, sometimes in the frown, between your eyes. Again, this can vary from a sudden and noticeable pain between your eyes the moment you put the binoculars down (when you suddenly feel your eyesight coming back to normal) to a lesser headache of varying intensity, which sometimes only manifests itself after a more pronounced use.
Anyway, be it a serious miscollimation (where you see double) or a lesser lack of alignment (varying from a "jump to norma" to varying levels of eyestrain or headache, a properly aligned and a properly adjusted binoculars should cause no eyestrain whatsoever, so if your unit does, it's a living evidence that it's not quite right, even is the barrels seem identical (we are talking about minute differences that are not detectable from the outside).
I'm sure more knowledgeable forum members will inform you in further detail, but basically: if you set up your binoculars properly (dioptre adjustment, cups up/down, correct interpupillary distance, proper eye positioning, etc.) the view should be easy and free of any strain, regardless of the configuration you choose, be it 6x30, 8x32, 10x42, etc.
It is true that some users prefer some formats for a series of reasons. For example, I like 7x35 or 7x42 because I find them "easy on the eye", the view is relaxed, there is a stable view with plenty of depth of field, but this is just a "personal sensory" preference. I've used 6x, 7x, 8x, 10x, 12x binoculars and, when properly adjusted, none has caused any strain, although I tend to find binoculars with smaller exit pupil and bigger magnification a less easy to use, while big exit pupil and lower magnification feels effortless and pleasurable to my eyes.